Recombinant Rat Beta-adrenergic receptor kinase 1 (Adrbk1)

1. these results expand the known function of GRK2, identifying a non-internalizing role to maintain peripheral DOR in an analgesically incompetent state. PMID: 27568556
2. Results show the expression level of swiprosin-1 associated to that of GRK2 and thereby to beta-adrenoceptor responsiveness. PMID: 27992454
3. a novel mechanism and model in which CAV1 phosphorylation facilitates CAV1 scaffolding and GRK2-CAV1 interaction, thus clustering eNOS within a complex that inhibits eNOS activity, is reported. PMID: 28162981
4. Neonatal rat cardiac fibroblasts infected with shGRK2 adenovirus were treated with isoproterenol, and changes in cAMP versus control were measured. Fibroblasts lacking GRK2 had enhanced cAMP compared with the isoproterenol-treated fibroblasts infected with LacZ adenovirus. Postischemic nuclear localization of NF[kappa]B is prevented when GRK2 is ablated, suggesting another nonclassical role for GRK2 in an injury setting. PMID: 27601479
5. Radiofrequency renal denervation inhibited GRK2 signaling which ameliorated myocardial perfusion injury. PMID: 27296507
6. Spinal GRK2 was an important regulator of CB2 receptor agonist-analgesia pathway in a model of bone cancer pain. PMID: 26935064
7. GRK2 knockdown leads to enhanced apoptosis of PC12 cells, indicating an essential role for GRK2 in chromaffin cell homeostasis/survival. PMID: 26849467
8. GRK2 may play an important role in regulating oxidative stress and apoptosis in cardiac myocytes and provides an additional novel mechanism for the beneficial effects of cardiac-targeted GRK2 inhibition to prevent the development of heart failure. PMID: 26631573
9. Suggest a common regulatory pattern for the beta(2)-AR/GRK2 which is independent of cellular type or pathology. PMID: 26248277
10. Suggest role for GRK2 in the regulating cardiac hypertrophy. PMID: 26224342
11. Our findings suggest a parallel increase in secretory activity between N-glycosylated and nonglycosylated a-amylase after b-adrenergic receptor activation. PMID: 25804000
12. Results suggest that the glial-neuronal GRK2 pathway is a potentially important new target for treating neuropathic pain, IL-1beta expressed in astrocytes plays a significant role in modulating this pathway PMID: 24216329
13. Both Galpha(q)/PKC- and GRK2/beta-arrestin1-dependent V(1A)R signaling were capable of inducing ERK1/2 phosphorylation. PMID: 23690069
14. endothelin receptor B and G protein coupled kinase-2 expression is increased in the mesentery of portal hypertensive rats PMID: 23599626
15. Results suggest that long-term exercise beginning at the prehypertensive stage improves vascular insulin sensitivity via downregulation of vascular GRK2 that may help to limit the progression of hypertension. PMID: 23913704
16. Grk2 is expressed by microglial cells and Schwann cells, cell types in which CXCR7 does not act as a classical chemokine receptor. PMID: 22940879
17. Data suggest that up-regulation of GRK2 expression/function is critical in regulatory aspects of vasoconstriction and vasorelaxation with advancing age; decline in vasorelaxation with age may involve up-regulation of GRK2 in vascular smooth muscle. PMID: 21951806
18. a novel role for IL-8 in inhibiting betaAR agonist-stimulated alveolar epithelial fluid transport via GRK2/PI3K-dependent mechanisms. PMID: 23221335
19. These data suggest cell type- and subcellular compartment-dependent differences in GRK/arrestin-mediated desensitization and signaling. PMID: 23139825
20. inflammation can produce a decrease in GRK2, such a mechanism could help explain a predilection to develop chronic pain, after resolution of acute inflammation PMID: 22796071
21. Data show that a dimeric Raf kinase inhibitor protein (RKIP) mutant displayed a higher affinity to G protein-coupled receptor kinase (GRK) 2, but a lower affinity to Raf1. PMID: 22610096
22. Regulation of the epithelial Na+ channel by the RH domain of G protein-coupled receptor kinase, GRK2, and Galphaq/11. PMID: 21464134
23. Data show that IL-1beta attenuates internalization of bradykinin B2 receptors, and induces downregulation of GRK2, in DRG neurons. PMID: 20883789
24. roles of GRK2 and arrestin2 as important regulators of UTP-stimulated P2Y(2)-receptor responsiveness in resistance arteries, emphasizing their potential importance in regulating vasoconstrictor signalling pathways implicated in vascular disease PMID: 20705669
25. Adrenal GRK2 lowering is an underlying mechanism for the beneficial sympathetic effects of exercise training in heart failure. PMID: 20304818
26. GRK2 is a key regulator of ET(A)R responsiveness in resistance arteries. PMID: 19748906
27. We identified completely novel cell-specific roles of GRK2 in regulating acute and chronic inflammatory hyperalgesia. PMID: 20147541
28. GRK2 mediates adrenergic insulin resistance and inhibition of GRK2 activity leads to increased insulin sensitivity both in cells and in animal model of insulin resistance. PMID: 19620130
29. After stimulation of G-protein-coupled receptors, RKIP dissociates from its known target, Raf-1, to associate with GRK-2 and block its activity PMID: 14654844
30. GRK2 expression is downregulated after cerebral hypoxia/ischemia. PMID: 15017017
31. the decline in beta-AR-mediated vasorelaxation in aging may be caused by both a reduction in caveolin-1 expression and a reduction in binding of GRK-2 by caveolin-1. PMID: 15626685
32. An important mechanism underlying impaired activity of eNOS in injured sinusoidal endothelial cells is defective phosphorylation of Akt caused by overexpression of GRK2 after injury. PMID: 16142243
33. GRK2 is involved in corticotropin releasing factor-induced desensitization by CRF receptor type 1 (CRFR1 in a cell line. PMID: 16195412
34. roles of G-protein-coupled receptor kinase-2, beta-arrestin-2, and the ubiquitin-proteasome pathway in beta-adrenergic receptor trafficking by exercise in rat adipocytes PMID: 16368719
35. oxidative stress associated with hyperglycemia causes increase in activity and expression of PKC; this leads to translocation of GRK2, phosphorylation of D1-like receptor, its uncoupling from G proteins and loss of responsiveness to agonist stimulation PMID: 16478977
36. These results indicate that conventional and novel PKCs attenuate lipolysis mediated by beta-adrenergic receptors, probably through inhibition of the beta1-adrenergic receptor system. PMID: 16500613
37. in old rats, tempol reduces oxidative stress and prevents GRK-2 membranous abundance and hyperphosphorylation of D1 receptors, resulting in restoration of D1 receptor-G protein coupling PMID: 16757732
38. Hydrogen peroxide treatment impairs GRK2 translation in a process that requires Cdk1 activation and involves the mTOR pathway. PMID: 16963227
39. Our data suggest that in cirrhosis-induced vasodilation, the AT1-R is desensitized by GRK-2 and beta-arrestin-2 and that changed patterns of phosphorylated Ca(2+) sensitizing proteins decrease Ca(2+) sensitivity. PMID: 17256744
40. Adrenal GRK2 activity is identified as a new sympatholytic target in experimental heart failure. PMID: 17322894
41. In conclusion, OGD-induced phosphoinositide-3-kinase-dependent phosphorylation of GRK2 on Ser670 is a novel mechanism leading to down-regulation of GRK2 protein via a proteasome-dependent pathway PMID: 17437535
42. Substrate specificity of Grk2 at cardiac myocyte receptors provides basis for distinct role in regulation of myocardial function. PMID: 17573483
43. TGFbeta signaling antagonizes Angiotensin II-induced vascular smooth muscle cells proliferation and migration through the inhibition of ERK phosphorylation. PMID: 19385060

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KEGG: rno:25238

STRING: 10116.ENSRNOP00000025847

UniGene: Rn.13010