Recombinant Rat Regulator of G-protein signaling 5 (Rgs5)

Code CSB-YP019657RA
MSDS
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Source Yeast
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Code CSB-EP019657RA
MSDS
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Source E.coli
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Code CSB-EP019657RA-B
MSDS
Size Pls inquire
Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP019657RA
MSDS
Size Pls inquire
Source Baculovirus
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Code CSB-MP019657RA
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
Rgs5
Uniprot No.
Alternative Names
Rgs5; Regulator of G-protein signaling 5; RGS5
Species
Rattus norvegicus (Rat)
Expression Region
1-181
Target Protein Sequence
MCKGLAALPH SCLERAKEIK IKLGILLQKP DSAVDLVIPY NEKPEKPAKA HKPSLEEVLQ WRQSLDKLLQ SNYGFASFKS FLKSEFSEEN LEFWVACENY KKIKSPIKMA EKAKQIYEEF IQTEAPKEVN IDHFTKDITM KNLVEPSPHS FDLAQKRIYA LMEKDSLPRF VRSEFYKELI N
Protein Length
Full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha.
Gene References into Functions
  1. AT1R activation results in translocation of RGS5 toward the plasma membrane, limiting AT1R-mediated vasoconstriction through its role in Gq/11 protein-dependent signaling. PMID: 29061726
  2. The enhancement of RGS5 activity by GPSM3 is maintained under these conditions. PMID: 25842189
  3. Rgs5 and Dlx1 represent novel molecular targets for the regulation of ductus arteriosus maturation and closure. PMID: 24489801
  4. RGS5 and VEGF coexpressed in the area of choroidal neovascularization, and RGS5 expressed later than VEGF. PMID: 21054999
  5. Results demonstrate that RGS5 expression is a critical mediator of both vascular smooth muscle contraction and potentially, arterial remodeling. PMID: 21593453
  6. Rgs5 and Notch3 are expressed in pericytes of developing and injured teeth and have roles along with vascular-derived stem cells during pulp healing PMID: 17939118
  7. After 2 days of aortic banding-induced hypertrophy, thoracic aorta lost expression of Rgs5, it returned to normal at 1 week and increased many fold at 28 days, indicating that RGS expression and function correlate with vascular remodeling. PMID: 18207159

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Subcellular Location
Cytoplasm. Membrane.
Database Links
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