Code | CSB-RA017713A740phHU |
Size | US$210 |
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Application | Recommended Dilution |
---|---|
WB | 1:500-1:5000 |
The phospho-PDGFRB (Y740) recombinant monoclonal antibody is a highly specific antibody against the human pY740-PDGFRB protein. This phosphorylated PDGFRB antibody was expressed through the clone of the DNA sequence encoding the pY740-PDGFRB monoclonal antibody into plasmids and subsequent transfection into cell lines. Its isotype matches with the rabbit IgG. This anti-pY740-PDGFRB antibody can be used in ELISA and WB applications and recognizes the human PDGFRB phosphorylated at Tyr 740 residue. It has been purified through affinity-chromatography.
When PDGF binds to the PDGFRB, it causes receptor tyrosine phosphorylation and the stable interaction of several signaling molecules, including PLC-gamma, the GAP, and PI3K. PDGFB and its receptor, PDGFRB, are necessary for the development of vascular mural cells such as pericytes and vascular smooth muscle cells. Three PDGFR tyrosine phosphorylation sites in the kinase insert domain have previously been identified as critical for the stable association of GAP and PI3K. Two of them, tyrosine Y740 and Y751, are necessary for PI3K stability, whereas Y771 is required for GAP binding.
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