Endocrine system disorders are a group of conditions that affect the normal functioning of endocrine glands, which include, but are not limited to, the thyroid, adrenal glands, pituitary gland, and gonads. These disorders are usually associated with abnormal hormone production, which may be either too high or too low, resulting in an imbalance in a variety of physiological functions in the body.
Common endocrine system disorders include diabetes mellitus, thyroid dysfunction (including hyperthyroidism and hypothyroidism), adrenal disorders (e.g., Addison's disease and Cushing's syndrome), pituitary dysfunction, gonadal disorders (e.g., polycystic ovary syndrome), osteoporosis, and obesity.
Drug research for endocrine system disorders has multiple targets and therapeutic strategies for different diseases and pathomechanisms. The following are some of the major disease drug development advances and their corresponding targets:
Measured by its binding ability in a functional ELISA. Immobilized Human GLP1R at 2 μg/mL can bind Anti-GLP1R recombinant antibody (CSB-RA009514MA1HU), the EC50 is 54.54-94.23 ng/mL.
Human GH1 protein his/myc tag (CSB-MP009407HU) captured on COOH chip can bind Human GHR protein Fc tag (CSB-MP009411HU) with an affinity constant of 6.1 nM as detected by LSPR Assay.
Measured by its binding ability in a functional ELISA. Immobilized PD-1 at 2 μg/ml can bind Anti-PD-1 recombinant antibody, the EC50 of human PD-1 protein is 6.087-7.854 ng/ml.
Measured by its binding ability in a functional ELISA. Immobilized human CLDN18.2 (CSB-MP005498HU(A5)) at 5 μg/ml can bind anti-CLDN18.2 recombinant Monoclonal Antibody (CSB-RA005498A1HU), the the EC50 is 5.225-9.256 ng/ml.
Human EGF protein captured on COOH chip can bind Human EGFR protein, his and Myc tag (CSB-MP007479HU) with an affinity constant of 11.9nM as detected by LSPR Assay.
Measured by its binding ability in a functional ELISA. Immobilized human GCGR at 2 μg/ml can bind Anti-GCGR recombinant antibody (CSB-RA009316A1HU), the EC50 is 3.747-6.666 ng/mL.
Measured by its binding ability in a functional ELISA. Immobilized PD-L1 at 2 μg/ml can bind Anti- PD-L1 mouse monoclonal antibody (CSB-MA878942A1m, antigen from E.coli), the EC50 of human PD-L1 protein is 1.252-1.653 ng/mL
Measured by its binding ability in a functional ELISA. Immobilized HER2 at 2 μg/ml can bind Trastuzumab, the EC50 is 2.179-2.825 ng/ml.
Product Name | Code | Target | Source | Tag Info |
---|---|---|---|---|
Recombinant Human ATP-binding cassette sub-family D member 1 (ABCD1) (Active) | CSB-CF001068HU | ABCD1 | in vitro E.coli expression system | C-terminal 10xHis-tagged |
Recombinant Human Angiopoietin-2 (ANGPT2) (Active) | CSB-MP001707HU(A4) | ANGPT2 | Mammalian cell | C-terminal 10xHis-tagged |
Recombinant Dog Angiopoietin-2 (ANGPT2) (Active) | CSB-MP001707DO | ANGPT2 | Mammalian cell | C-terminal 6xHis-tagged |
Recombinant Human Programmed cell death 1 ligand 1 (CD274), partial (Active) | CSB-MP878942HU1 | CD274 | Mammalian cell | C-terminal hFc-tagged |
Recombinant Human CD276 antigen (CD276), partial (Active) | CSB-MP733578HU | CD276 | Mammalian cell | C-terminal hFc-Myc-tagged |
Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active) | CSB-AP005181HU | CD40 | Mammalian cell | C-terminal Fc-tagged |
Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active) | CSB-MP004936HU1 | CD40 | Mammalian cell | C-terminal hFc-tagged |
Recombinant Human CD40 ligand (CD40LG), partial (Active) | CSB-AP005191HU | CD40LG | E.coli | Tag-Free |
Recombinant Human CD40 ligand (CD40LG), partial (Active) | CSB-MP004937HU3 | CD40LG | Mammalian cell | N-terminal hFc-Flag-tagged |
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active) | CSB-AP005201HU | CD47 | Mammalian cell | C-terminal 6xHis-tagged |
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active) | CSB-AP005211HU | CD47 | Mammalian cell | C-terminal Fc-tagged |
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active) | CSB-MP004940HU | CD47 | Mammalian cell | C-terminal hFc-tagged |
Recombinant Human Cadherin-17 (CDH17), partial (Active) | CSB-MP613267HU | CDH17 | Mammalian cell | C-terminal 10xHis-tagged |
Recombinant Macaca fascicularis Cadherin 17 (CDH17), partial (Active) | CSB-MP4664MOV | CDH17 | Mammalian cell | C-terminal 10xHis-tagged |
Recombinant Human Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) (E398K) (Active) | CSB-MP005165HU | CEACAM5 | Mammalian cell | C-terminal 10xHis-tagged |
Recombinant Human Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) (Active) | CSB-MP005166HU | CEACAM6 | Mammalian cell | C-terminal 10xHis-tagged |
Recombinant Macaca fascicularis Claudin (CLDN18)-VLPs (Active) | CSB-MP4304MOV | CLDN18 | Mammalian cell | N-terminal 6xHis-tagged (This tag can be tested only under denaturing conditions) |
Recombinant Mouse Claudin-18 (Cldn18)-VLPs (Active) | CSB-MP005498MO(F3) | Cldn18 | Mammalian cell | N-terminal 6xHis-tagged (This tag can be tested only under denaturing conditions) |
Recombinant Human Claudin-6 (CLDN6)-VLPs (Active) | CSB-MP005508HU(A4) | CLDN6 | Mammalian cell | C-terminal 10xHis-tagged (This tag can be tested only under denaturing conditions) |
Recombinant Human Claudin-6 (CLDN6)-VLPs, Fluorescent (Active) | CSB-MP005508HU(A4)f4 | CLDN6 | Mammalian cell | C-terminal GFP-tagged (This tag can be tested only under denaturing conditions) |
HEK293T/Human CLDN6 Stable Cell Line
CSB-SC005508HU
Untransfected HEK293T cells (green line) and transfected Human CLDN6 HEK293T stable cells (red line) were stained with anti-CLDN6/9 antibody (CSB-RA005508MA1HU) (2µg/1*106 cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.
HEK293T/Human CDH17 Stable Cell Line
CSB-SC613267HU2
Untransfected HEK293T cells (green line) and transfected Human CDH17 HEK293T stable cells (red line) were stained with anti-CDH17 antibody (CSB-RA613267MA1HU) (2µg/1*106 cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.
Untransfected KATO3 cells surface (green line), transfected Human CLDN18.2 KATO3 stable cells surface (red line) and transfected Human CLDN18.1 NIH-3T3 stable cells surface (blue line) were stained with anti-CLDN18.2 antibody (2µg/1*106 cells).
Overlay histogram showing Jurkat cells stained with CSB-RA159341A0HU (red line) at 1:50.
Overlay Peak curve showing Jurkat cells surface stained with CSB-RA244537A0HU (red line) at 1:50.
Overlay Peak curve showing Hela cells surface stained with CSB-RA011087MA1HU (red line) at 1:50.
Product Name | Code | Target | Species Reactivity | Tested Applications |
---|---|---|---|---|
ANGPT2 Recombinant Monoclonal Antibody | CSB-RA191985A0HU | ANGPT2 | Human | ELISA, IHC |
ANGPT2 Recombinant Monoclonal Antibody | CSB-RA001707MA01HU | ANGPT2 | Human | ELISA |
CD247 Recombinant Monoclonal Antibody | CSB-RA244537A0HU | CD247 | Human | ELISA, FC |
CD274 Recombinant Monoclonal Antibody | CSB-RA977797A0HU | CD274 | Human | ELISA, WB, IHC |
CD274 Recombinant Monoclonal Antibody | CSB-RA878942MA1HU | CD274 | Human | ELISA, IHC, FC |
CD40 Recombinant Monoclonal Antibody | CSB-RA004936MA1HU | CD40 | Human | ELISA, IF, FC |
CD47 Recombinant Monoclonal Antibody | CSB-RA802124A0HU | CD47 | Human | ELISA, WB, IHC, IF |
CDH17 Recombinant Monoclonal Antibody | CSB-RA613267MA1HU | CDH17 | Human | ELISA,FC |
CDH6 Recombinant Monoclonal Antibody | CSB-RA005055MA1HU | CDH6 | Human | ELISA |
CEACAM5 Recombinant Monoclonal Antibody | CSB-RA005165MA3HU | CEACAM5 | Human | ELISA, IF, FC |
CEACAM5 Recombinant Monoclonal Antibody | CSB-RA005165MA1HU | CEACAM5 | Human | ELISA |
CLDN18 Recombinant Monoclonal Antibody | CSB-RA005498A2HU | CLDN18 | Human | ELISA, FC |
Claudin-18.2 Recombinant Monoclonal Antibody | CSB-RA005498A1HU | CLDN18 | Human | ELISA, FC |
CTLA4 Recombinant Monoclonal Antibody | CSB-RA213310A0HU | CTLA4 | Human | ELISA, IHC |
CTLA4 Recombinant Monoclonal Antibody | CSB-RA006163MA1HU | CTLA4 | Human, Mouse | ELISA, WB, IF, FC |
Phospho-EGFR (Y1092) Recombinant Monoclonal Antibody | CSB-RA007479A1092phHU | EGFR | Human | ELISA, WB |
Phospho-EGFR (Y1068) Recombinant Monoclonal Antibody | CSB-RA007479A1068phHU | EGFR | Human | ELISA, WB |
EGFR Recombinant Monoclonal Antibody | CSB-RA159341A0HU | EGFR | Human | ELISA, WB, IHC, IF, FC |
EGFR Recombinant Monoclonal Antibody | CSB-RA794061A0HU | EGFR | Human | ELISA, WB, IHC |
EGFR Recombinant Monoclonal Antibody | CSB-RA159341MA1HU | EGFR | Human | ELISA, IHC, FC |
Product Name | Code | Target | Detection Range | Sensitivity |
---|---|---|---|---|
Human Angiopoietin 2,ANG-2 ELISA Kit | CSB-E04500h | ANGPT2 | 39 pg/mL-2500 pg/mL | 9.75 pg/mL |
Rat Angiopoietin 2,ANG-2 ELISA Kit | CSB-E07304r | ANGPT2 | Request Information | Request Information |
Mouse Angiopoietin 2,ANG-2 ELISA Kit | CSB-E07305m | ANGPT2 | 0.156 pg/mL-10 pg/mL | 0.039 pg/mL |
Pig Angiopoietin 2,ANG-2 ELISA Kit | CSB-E08460p | ANGPT2 | 0.94 ng/mL-60 ng/mL | 0.235 ng/mL |
Human Tyrosine-protein kinase receptor UFO (AXL) ELISA Kit | CSB-EL002476HU | AXL | 31.25 pg/mL-2000 pg/mL | 7.81 pg/mL |
Mouse Tyrosine-protein kinase receptor UFO(AXL) ELISA Kit | CSB-EL002476MO | AXL | 31.25 pg/ml-2000 pg/ml | 7.81 pg/ml |
Human T-cell surface glycoprotein CD3 zeta chain (CD247) ELISA kit | CSB-EL004904HU | CD247 | 0.156 ng/mL-10 ng/mL | 0.039 ng/mL |
Human Programmed Death Ligand-1(PD-L1/CD274) ELISA Kit | CSB-E13644h | CD274 | 15.6 pg/mL-1000 pg/mL | 3.9 pg/mL |
Mouse Programmed cell death 1 ligand 1(CD274) ELISA kit | CSB-EL004911MO | CD274 | 31.25 pg/mL-2000 pg/mL | 7.81 pg/mL |
Human Soluble CD276,sCD276/sB7-H3 ELISA Kit | CSB-E14285h | CD276 | 3.12 ng/mL-200 ng/mL | 0.78 ng/mL |
Human soluble cluster of differentiation 28,sCD28 ELISA Kit | CSB-E09296h | CD28 | 0.625 ng/mL-40 ng/mL | 0.156 ng/mL |
Mouse Tumor necrosis factor receptor superfamily member 5(CD40) ELISA kit | CSB-EL004936MO | CD40 | Request Information | Request Information |
Human Soluble Cluster of differentiation 40 ligand,sCD40L ELISA Kit | CSB-E04716h | CD40LG | 0.312 ng/mL-20 ng/mL | 0.078 ng/mL |
Mouse Soluble Cluster of differentiation 40 ligand,sCD40L ELISA Kit | CSB-E04717m | CD40LG | 0.274 ng/ml-200 ng/ml. | 0.274 ng/ml. |
Rat Soluble Cluster of differentiation 40 ligand,sCD40L ELISA Kit | CSB-E07395r | CD40LG | 1.87 ng/mL-120 ng/mL | 0.47 ng/mL |
Human Leukocyte surface antigen CD47(CD47) ELISA kit | CSB-EL004940HU | CD47 | 3.12 pg/mL-200 pg/mL | 0.78 pg/mL |
Mouse Leukocyte surface antigen CD47(CD47) ELISA kit | CSB-EL004940MO | CD47 | 15.6 pg/mL-1000 pg/mL | 3.9 pg/mL |
Human carcinoembryonic antigen,CEA ELISA Kit | CSB-E04767h | CEACAM5 | 5 ng/mL-120 ng/mL | 2 ng/mL |
Mouse carcinoembryonic antign,CEA ELISA Kit | CSB-E13925m | CEACAM5 | 62.5 pg/mL-4000 pg/mL | 15.6 pg/mL |
Human Carcinoembryonic antigen-related cell adhesion molecule 6(CEACAM6) ELISA kit | CSB-EL005166HU | CEACAM6 | 0.83 ng/mL-20 ng/mL | 0.33 ng/mL |
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