New Power in the Fight Against Cancer: Spotlight on Rising Stars of ADC Drugs at the 2024 ASCO Annual MeetingASCO Annual Meeting, as a wind vane in the field of oncology, attracts global attention every year. 2024 ASCO Annual Meeting is especially notable for the clinical progress reports of ADC drugs. From CLDN18.2 to HER2 to ...
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What is a His Tag? A Guide from Definition to ApplicationsAfter the rise of recombinant DNA technology, scientists faced an important problem: how to purify the expressed recombinant proteins efficiently. Traditional protein purification methods are often cumbersome and ineffi...
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What Is Protein Characterization: Definition, Examples, Methods, and TechniquesProteins serve as the carriers of life and the executors of biological functions, playing a crucial role in maintaining normal physiological activities, including cytoskeleton construction, enzymatic catalysis, signal tr...
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What is Myc Tag: Definition, Function, Applications & Comparison with Other Epitope TagsThe development of the Myc tag stemmed from the need for a small, recognizable epitope that could be fused to proteins, enabling researchers to detect and purify these target proteins using anti-Myc antibodies. ...
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What Are the Best Antibody Purification Methods for Your Research Needs?Antibodies are indispensable tools in biological research, medicine, and various industrial applications. Highly pure antibodies give rise to reliable experimental outcomes and rigorous clinical data, ensuring safety and...
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CT83/KK-LC-1: a Promising Therapeutic Target of CTAs Family, Currently in Clinical Research for Breast, Lung, Gastric Cancers, and Beyond!Cancer Testis Antigens (CTAs) are proteins primarily expressed in testicular tissue but not in other normal tissues. However, CTAs show heightened expression in various tumors, with many having tumorigenic properties. Am...
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IL-6: an Important Participant in the Inflammatory Cascade, One of the Most Functional Cytokines in Various Diseases Research!On February 22, 2024, Cell Reports published a significant article titled "Insights into IL-6 Signaling Inhibition with Therapeutic Antibodies." This study highlights how antibodies like Tocilizumab and Sarilumab block t...
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Exploring Protein-Protein Interactions: A Comprehensive Guide to Understanding and Utilizing ItProteins, the executor of life activities, efficiently execute cellular functions through interactions, frequently in the form of protein-protein interactions. Understanding any cellular process requires knowing which pr...
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Interleukin 4 receptor (IL-4R/IL-4Ra): a Multifunctional Target of Cytokines, Suggesting Diverse Potential in Asthma, Rhinitis, Viral, and Tumor Research!On January 26, 2024, a pharmaceutical company license two promising products: an anti-TSLP monoclonal antibody and an anti-IL-4Ra monoclonal antibody. These aim to treat respiratory disorders like asthma and chronic obst...
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In Vivo vs. In Vitro: Choosing the Right Experimental Model for Your ResearchResearchers conduct experiments using various experimental models, which can be categorized into two main types: in vivo and in vitro based on where the research is conducted and the type of biological system being studi...
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