AKT3

AKT3, or protein kinase Bγ, is the third member of the protein kinase B family.AKT3 is expressed predominantly in the brain, testis, and certain types of cancer cells. Its mechanism of action is similar to that of AKT1 and AKT2, which is recruited to the cell membrane by binding to PIP3 produced by activation of PI3K (phosphatidylinositol 3-kinase) and subsequently activated by phosphorylation by upstream kinases such as PDK1. Activated AKT3 is capable of phosphorylating a variety of substrates, including BAD proteins that promote cell survival, FOXO transcription factors, and components of the mTOR signalling pathway.Signalling pathways in which AKT3 is involved include the PI3K/AKT/mTOR pathway, which plays a key role in cell growth, metabolism, survival, and proliferation.AKT3 has also been implicated in neural development, synaptic plasticity, and cognitive functions. Biologically, AKT3 is essential for normal function and development of the nervous system. Aberrant expression or dysfunction of AKT3 has been associated with a variety of diseases, including neurodegenerative disorders, psychiatric disorders, and some types of cancers, and the regulation of AKT3 activity is currently a hot area of drug discovery and disease treatment research.