BIRC5, baculovirus IAP repeat-sequence-containing protein 5, is a member of the inhibitor of apoptosis (IAPs) family of proteins, which negatively regulates apoptosis or programmed cell death, mainly by inhibiting caspase activation.BIRC5 is highly expressed in a variety of tumours, including lung cancer and hepatocellular carcinoma and has been implicated in the regulation of tumour stem cells (CSCs), the epithelial mesenchymal transition (EMT) process is closely related. Its mechanism of action involves interactions with multiple signalling pathways, such as the Wnt/β-catenin signalling pathway, which plays a key role in tumour development, cell proliferation and apoptosis.The biological significance of BIRC5 lies in its roles in cell survival, tumour development, DNA damage repair, and it is a potential target in tumour therapy, and the changes in its expression level are closely related to the prognosis of many tumours. and the changes in its expression level are closely related to the prognosis of many tumours.
Recombinant Mouse Baculoviral IAP repeat-containing protein 5 (Birc5) (CSB-EP002706MOa0)
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
BIRC5 Recombinant Monoclonal Antibody (CSB-RA209144A0HU)
Validated Data
IHC image of CSB-RA209144A0HU diluted at 1:100 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
The following BIRC5 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
BIRC5 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA002706GA01HU | BIRC5 Antibody |
Human,Mouse,Rat | ELISA,WB,IHC |
CSB-PA644556 | Phospho-BIRC5 (Thr117) Antibody |
Human,Mouse,Rat | ELISA,WB |
CSB-PA009313 | Phospho-BIRC5 (T34) Antibody |
Human,Mouse,Rat | WB, ELISA |
CSB-PA009314 | Phospho-BIRC5 (T117) Antibody |
Human,Mouse,Rat | IHC, IF, ELISA |
CSB-PA009320 | BIRC5 Antibody |
Human,Mouse,Rat | IHC, ELISA |
CSB-PA009326 | BIRC5 Antibody |
Human,Mouse,Rat | WB, IHC, IF, ELISA |
CSB-PA080180 | BIRC5 Antibody |
Human,Mouse,Rat | IHC, ELISA |
CSB-MA080214 | BIRC5 Monoclonal Antibody |
Human,Rat | ELISA,WB,IHC |
CSB-PA159155 | BIRC5 Antibody |
Human,Mouse,Rat | ELISA,IHC |
CSB-PA968757 | BIRC5 Antibody |
Human,Mouse,Rat | ELISA,WB,IHC |
CSB-PA07249A0Rb | BIRC5 Antibody |
Human | ELISA, IF |
CSB-PA07249B0Rb | BIRC5 Antibody, HRP conjugated |
Human | ELISA |
CSB-PA07249C0Rb | BIRC5 Antibody, FITC conjugated |
Human | |
CSB-RA209144A0HU | BIRC5 Recombinant Monoclonal Antibody |
Human | ELISA, IHC |
BIRC5 Antibodies for Mus musculus (Mouse)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA002706HA01MO | Birc5 Antibody |
Mouse, Human | ELISA, WB |
BIRC5 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP002706HU CSB-BP002706HU CSB-MP002706HU CSB-EP002706HU-B |
Recombinant Human Baculoviral IAP repeat-containing protein 5 (BIRC5) |
Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-EP002706HU | Recombinant Human Baculoviral IAP repeat-containing protein 5 (BIRC5) |
E.coli |
BIRC5 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-EP002706MO | Recombinant Mouse Baculoviral IAP repeat-containing protein 5 (Birc5) |
E.coli |
CSB-YP002706MO | Recombinant Mouse Baculoviral IAP repeat-containing protein 5 (Birc5) |
Yeast |
CSB-BP002706MO CSB-MP002706MO CSB-EP002706MO-B |
Recombinant Mouse Baculoviral IAP repeat-containing protein 5 (Birc5) |
Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-EP002706MOa0 | Recombinant Mouse Baculoviral IAP repeat-containing protein 5 (Birc5) |
E.coli |
BIRC5 Proteins for Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Code | Product Name | Source |
---|---|---|
CSB-YP722377PYX CSB-EP722377PYX CSB-BP722377PYX CSB-MP722377PYX CSB-EP722377PYX-B |
Recombinant Pongo abelii Baculoviral IAP repeat-containing protein 5 (BIRC5) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
BIRC5 Proteins for Felis catus (Cat) (Felis silvestris catus)
Code | Product Name | Source |
---|---|---|
CSB-YP764222CA CSB-EP764222CA CSB-BP764222CA CSB-MP764222CA CSB-EP764222CA-B |
Recombinant Cat Baculoviral IAP repeat-containing protein 5 (BIRC5) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
BIRC5 Proteins for Bos taurus (Bovine)
Code | Product Name | Source |
---|---|---|
CSB-YP764265BO CSB-EP764265BO CSB-BP764265BO CSB-MP764265BO CSB-EP764265BO-B |
Recombinant Bovine Baculoviral IAP repeat-containing protein 5 (BIRC5) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
BIRC5 Proteins for Canis lupus familiaris (Dog) (Canis familiaris)
Code | Product Name | Source |
---|---|---|
CSB-YP814170DO CSB-EP814170DO CSB-BP814170DO CSB-MP814170DO CSB-EP814170DO-B |
Recombinant Dog Baculoviral IAP repeat-containing protein 5 (BIRC5) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
BIRC5 Proteins for Rattus norvegicus (Rat)
Code | Product Name | Source |
---|---|---|
CSB-YP864316RA CSB-EP864316RA CSB-BP864316RA CSB-MP864316RA CSB-EP864316RA-B |
Recombinant Rat Baculoviral IAP repeat-containing protein 5 (Birc5) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
BIRC5 Proteins for Sus scrofa (Pig)
Code | Product Name | Source |
---|---|---|
CSB-YP880898PI CSB-EP880898PI CSB-BP880898PI CSB-MP880898PI CSB-EP880898PI-B |
Recombinant Pig Baculoviral IAP repeat-containing protein 5 (BIRC5) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |