ELK3, a member of the ETS family of transcription factors, is distinguished by its ETS domain, which enables it to recognize and bind specific DNA sequences to regulate gene expression. Structurally, ELK3 comprises multiple domains that facilitate protein-protein interactions and subcellular localization. Functionally, ELK3 serves as a crucial regulator of cellular processes such as proliferation, differentiation, and apoptosis. Acting as either a transcriptional activator or repressor, its activity is determined by the cellular context and its interactions with other proteins. Within the signaling pathway, ELK3 is typically activated through the MAPK signaling cascade. Upon exposure to extracellular stimuli like growth factors or hormones, the MAPK pathway is triggered, leading to the phosphorylation and activation of MAPK proteins. Subsequently, activated MAPKs phosphorylate ELK3, enhancing its transcriptional activity. This phosphorylation event triggers conformational changes in ELK3, enabling it to bind more efficiently to its target DNA sequences. Once activated, ELK3 regulates the expression of genes involved in cellular growth, proliferation, and differentiation, thereby playing a pivotal role in cellular responses to external stimuli and the maintenance of tissue homeostasis.
Recombinant Human Potassium voltage-gated channel subfamily H member 8 (KCNH8), partial
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
The following ELK3 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
ELK3 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA008025 | Phospho-ELK3 (S357) Antibody |
Human,Mouse,Monkey | WB, IHC, IF, ELISA |
CSB-PA008026 | ELK3 Antibody |
Human,Mouse | IF, ELISA |
CSB-PA007606LA01HU | ELK3 Antibody |
Human | ELISA, IHC |
CSB-PA007606LB01HU | ELK3 Antibody, HRP conjugated |
Human | ELISA |
CSB-PA007606LD01HU | ELK3 Antibody, Biotin conjugated |
Human | ELISA |
ELK3 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP007606HU CSB-EP007606HU CSB-BP007606HU CSB-MP007606HU CSB-EP007606HU-B |
Recombinant Human ETS domain-containing protein Elk-3 (ELK3) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |