HDAC6, also known as histone deacetylase 6, is a class IIb enzyme with two deacetylation functional domains. It consists of 1215 amino acid residues and contains two nuclear export signals (NES), two tandem deacetylation catalytic domains (DD1 and DD2), a serine-glutamate-containing tetradecapeptide repeat region (SE14), and a zinc finger structure (ZnF-UBP). Although HDAC6 has a nuclear localization signal (NLS), it mainly functions in the cytoplasm. HDAC6's unique functions include catalyzing the deacetylation of non-histone substrates, which are involved in various physiological and pathological processes such as cell movement, signal transduction, and protein repair and degradation. Its main substrates include α-tubulin, paxillin, and heat shock protein 90 (Hsp90). HDAC6 is involved in a wide range of signaling pathways, including cell movement and migration, protein repair and degradation, cell signaling, and immune response. The activity of HDAC6 is regulated by various post-translational modifications such as phosphorylation, acetylation, ubiquitination, and SUMOylation. Abnormal expression and activity of HDAC6 are associated with various disease states, including cancer, neurodegenerative diseases, renal fibrosis, autoimmune and inflammatory diseases. Therefore, HDAC6 is considered a potential therapeutic target, and its specific inhibitors show promise in treating these diseases.
The following HDAC6 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
HDAC6 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA010242GA01HU | HDAC6 Antibody |
Human | ELISA,WB,IHC |
CSB-PA010242ESR1HU | HDAC6 Antibody |
Human | ELISA, IHC |
CSB-PA002895 | HDAC6 Antibody |
Human,Mouse | WB, IHC, IF, ELISA |
CSB-PA002915 | HDAC6 Antibody |
Human,Mouse | WB, IHC, IF, ELISA |
CSB-PA006360 | Phospho-HDAC6 (S22) Antibody |
Human,Mouse | WB, IHC, IF, ELISA |
CSB-PA144078 | HDAC6 Antibody |
Human | ELISA,IHC |
CSB-RA010242A0HU | HDAC6 Recombinant Monoclonal Antibody |
Human | ELISA, WB, IHC, IP |
HDAC6 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP010242HU CSB-BP010242HU CSB-MP010242HU CSB-EP010242HU-B |
Recombinant Human Histone deacetylase 6 (HDAC6), partial |
Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-EP010242HU | Recombinant Human Histone deacetylase 6 (HDAC6), partial |
E.coli |
CSB-EP010242HU1 | Recombinant Human Histone deacetylase 6 (HDAC6),Partial |
E.coli |