IL23A, or interleukin 23 alpha, is a gene located on chromosome 12. The protein encoded by this gene is a subunit of interleukin 23 (IL-23), which binds to the p40 subunit encoded by the IL12B gene to form the biologically active IL-23 heterodimer.IL-23 activates downstream signalling by binding to its specific receptor IL23R, mainly through the JAK-STAT pathway, especially STAT3 and STAT4 IL23A plays a key role in regulating the immune response, particularly in promoting Th17 cell-mediated immune responses.Th17 cells are closely associated with the development of a variety of inflammatory and autoimmune diseases, such as inflammatory bowel disease, psoriasis and multiple sclerosis . In addition, IL-23 plays a role in tumour immunity, influencing tumour growth and the immunosuppressive environment. Therefore, IL23A is an important molecule in the study of immune regulation and treatment of related diseases.
Recombinant Guinea pig Interleukin-23 subunit alpha (IL23A) (CSB-EP757211GU)
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
IL23A Recombinant Monoclonal Antibody (CSB-RA251959A0HU)
Validated Data
Western Blot
Positive WB detected in: THP-1 whole cell lysate
All lanes: IL23 antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 21 kDa
Observed band size: 21 kDa
Human Interleukin-23 subunit alpha(IL-23A) Elisa kit (CSB-E17339h)
Validated Data
Code: CSB-E17339h
Size: 96T,5×96T,10×96T
Sensitivity: 15.6 pg/mL
Detection Range: 62.5 pg/mL-4000 pg/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
The following IL23A reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
IL23A Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA06719A0Rb | IL23A Antibody |
Human | ELISA, IHC, IF |
CSB-PA06719B0Rb | IL23A Antibody, HRP conjugated |
Human | ELISA |
CSB-PA06719C0Rb | IL23A Antibody, FITC conjugated |
Human | |
CSB-PA06719D0Rb | IL23A Antibody, Biotin conjugated |
Human | ELISA |
CSB-RA251959A0HU | IL23A Recombinant Monoclonal Antibody |
Human | ELISA, WB |
IL23A Antibodies for Mus musculus (Mouse)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA863641ZA01MO | Il23a Antibody |
Mus musculus | ELISA, WB (ensure identification of antigen) |
IL23A Antibodies for Cavia porcellus (Guinea pig)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA757211ZA01GP | IL23A Antibody |
Cavia porcellus | ELISA, WB (ensure identification of antigen) |
IL23A Proteins for Equus caballus (Horse)
Code | Product Name | Source |
---|---|---|
CSB-YP727376HO CSB-EP727376HO CSB-BP727376HO CSB-MP727376HO CSB-EP727376HO-B |
Recombinant Horse Interleukin-23 subunit alpha (IL23A) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL23A Proteins for Cavia porcellus (Guinea pig)
Code | Product Name | Source |
---|---|---|
CSB-YP757211GU CSB-BP757211GU CSB-MP757211GU CSB-EP757211GU-B |
Recombinant Guinea pig Interleukin-23 subunit alpha (IL23A) |
Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-EP757211GU | Recombinant Guinea pig Interleukin-23 subunit alpha (IL23A) |
E.coli |
IL23A Proteins for Rattus norvegicus (Rat)
Code | Product Name | Source |
---|---|---|
CSB-YP852813RA CSB-EP852813RA CSB-BP852813RA CSB-MP852813RA CSB-EP852813RA-B |
Recombinant Rat Interleukin-23 subunit alpha (Il23a) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL23A Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP863641MO CSB-BP863641MO CSB-MP863641MO CSB-EP863641MO-B |
Recombinant Mouse Interleukin-23 subunit alpha (Il23a) |
Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-EP863641MO | Recombinant Mouse Interleukin-23 subunit alpha (Il23a), partial |
E.coli |
CSB-CF863641MO | Recombinant Mouse Interleukin-23 subunit alpha (Il23a) |
in vitro E.coli expression system |
IL23A Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP868278HU CSB-EP868278HU CSB-BP868278HU CSB-MP868278HU CSB-EP868278HU-B |
Recombinant Human Interleukin-23 subunit alpha (IL23A) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-AP004661HU | Recombinant Human IL23A & IL12B Heterodimer Protein (Active) |
Mammalian cell |
IL23A Proteins for Sus scrofa (Pig)
Code | Product Name | Source |
---|---|---|
CSB-YP873568PI CSB-BP873568PI CSB-MP873568PI CSB-EP873568PI-B |
Recombinant Pig Interleukin-23 subunit alpha (IL23A) |
Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-CF873568PI | Recombinant Pig Interleukin-23 subunit alpha (IL23A) |
in vitro E.coli expression system |
IL23A ELISA Kit for Homo sapiens (Human)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E17339h | Human Interleukin-23 subunit alpha(IL-23A) Elisa kit |
serum, plasma, cell culture supernates, tissue homogenates, cell lysates | 15.6 pg/mL |
IL23A ELISA Kit for Sus scrofa (Pig)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-EL011638PI | Pig Interleukin-23 subunit alpha(IL23A) ELISA kit |
serum, plasma, tissue homogenates | 7.8 pg/mL |