MUC16, or mucin 16, is a highly glycosylated transmembrane mucin and a member of the mucin family. It was first identified in ovarian epithelial carcinoma cell lines and is expressed in a variety of tumours, especially highly expressed in more than 80% of ovarian cancers.The mechanism of action of MUC16 involves the regulation of cell proliferation, migration, invasion and metastasis, and its aberrant expression is closely related to tumourigenesis, proliferation and metastasis.MUC16 enhances the cancer cells' proliferation, invasion and metastasis. In addition, MUC16 may also be associated with the Wnt/β-catenin signalling pathway, affecting tumour growth or metastasis. Biologically, MUC16 not only plays a role in maintaining the protective barrier function of epithelial cells, but also its role in the tumour immune microenvironment has been increasingly valued as a potential target in tumour therapy and immune regulation.
Recombinant Human Mucin-16 (MUC16), partial (CSB-MP704410HU3)
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
The following MUC16 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
MUC16 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA10657A0Rb | MUC16/CA125 Antibody |
Human | ELISA, IHC |
CSB-PA10657B0Rb | MUC16/CA125 Antibody, HRP conjugated |
Human | ELISA |
CSB-PA10657C0Rb | MUC16/CA125 Antibody, FITC conjugated |
Human | |
CSB-PA015219GA01HU | MUC16/CA125 Antibody |
Human | ELISA,WB |
CSB-PA899266 | MUC16/CA125 Antibody |
Human | ELISA,IF |
CSB-PA070303 | MUC16/CA125 Antibody |
Human | IF, ELISA |
CSB-PA268943 | MUC16/CA125 Antibody |
Human | ELISA,IHC |
CSB-RA941216A0HU | MUC16/CA125 Recombinant Monoclonal Antibody |
Human | ELISA, IHC |
CSB-RA973154A0HU | MUC16/CA125 Recombinant Monoclonal Antibody |
Human | ELISA, IHC |
MUC16 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-MP704410HU3 | Recombinant Human Mucin-16 (MUC16), partial |
Mammalian cell |
CSB-MP704410HU3c7 | Recombinant Human Mucin-16 (MUC16), partial (Active) |
Mammalian cell |
CSB-EP704410HU3 | Recombinant Human Mucin-16 (MUC16), partial |
E.coli |
MUC16 ELISA Kit for Homo sapiens (Human)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E04771h | Human Carbonhydrate Antigen 125(CA125) ELISA Kit |