RNF31, also known as ZIBRA or HOIP, is an E3 ubiquitin ligase belonging to the RBR protein family. It is highly conserved in evolution and is located on human chromosome 14 at 14q11.2. It encodes 1072 amino acids and has a molecular weight of approximately 118 kDa. RNF31 is expressed at low levels in all tissues and organs, but its expression level in breast cancer cells is significantly higher than that in normal breast cells, suggesting that it is associated with the occurrence and development of tumors. RNF31 is involved in the ubiquitination process, which is a post-translational modification of proteins that affects the amino acid residues of target proteins, and thus participates in various physiological functions. Abnormal ubiquitination expression may promote cancer formation. The signaling pathways involved in RNF31 include the NF-κB pathway, whose downregulation can inhibit the activation of the TNF-α-stimulated NF-κB pathway and affect cell apoptosis; the TNF signaling pathway and the Toll-like receptor signaling pathway, both of which are crucial in inflammatory responses and immune responses; and the epidermal growth factor receptor EGFR signaling pathway, where RNF31 can regulate EGFR and its downstream signaling, including the expression of NF-κB, p-STAT3, MAPK, and p-MAPK proteins. These functions and signaling pathways suggest that RNF31 plays an important role in cell growth, immune response, and tumor development, and its research can help develop new cancer treatment strategies, especially in the treatment of breast cancer and other related cancers.
The following RNF31 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
RNF31 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA856927LA01HU | RNF31 Antibody |
Human | ELISA, IHC, IF |
CSB-PA856927LD01HU | RNF31 Antibody, Biotin conjugated |
Human | ELISA |
CSB-PA856927LC01HU | RNF31 Antibody, FITC conjugated |
Human | |
CSB-PA856927LB01HU | RNF31 Antibody, HRP conjugated |
Human | ELISA |
RNF31 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP846072MO CSB-EP846072MO CSB-BP846072MO CSB-MP846072MO CSB-EP846072MO-B |
Recombinant Mouse E3 ubiquitin-protein ligase RNF31 (Rnf31), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
RNF31 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP856927HU CSB-EP856927HU CSB-BP856927HU CSB-MP856927HU CSB-EP856927HU-B |
Recombinant Human E3 ubiquitin-protein ligase RNF31 (RNF31), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |