SERPINA1, or α1-antitrypsin, is a serine protease inhibitor synthesised mainly in the liver. It is a member of the SERPIN family and inhibits serine proteases, such as trypsin, by forming a stable complex with them.The mechanism of action of SERPINA1 is that it acts as a substrate for proteases, and the arginine residue in its active site irreversibly covalently binds to the serine active site of the protease to inhibit the protease activity. This inhibition plays an important role in preventing tissue damage and inflammatory responses.The role of SERPINA1 in signalling involves a variety of biological processes, including anti-inflammatory, anti-coagulant and apoptotic cell death. In a biological sense, SERPINA1 is particularly important for the maintenance of lung health, and its inherited deficiency can lead to respiratory diseases such as emphysema. In addition, polymorphisms in SERPINA1 have been associated with a variety of diseases, including liver disease and certain types of cancer. In the clinic, the activity level of SERPINA1 can be used as a biomarker for certain diseases for disease diagnosis and treatment monitoring.
Recombinant Rat Alpha-1-antiproteinase (Serpina1) (CSB-EP021053RA)
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
SERPINA1 Antibody (CSB-PA799490)
Validated Data
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA799490(SERPINA1 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA799490(SERPINA1 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
Gel: 8%SDS-PAGE,Lysate: 40 μg,,Primary antibody: CSB-PA799490(SERPINA1 Antibody) at dilution 1/250 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 20 seconds
The following SERPINA1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
SERPINA1 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA021053GA01HU | SERPINA1 Antibody |
Human,Mouse,Rat | ELISA,WB |
CSB-PA004671 | SERPINA1 Antibody |
Human | WB, ELISA |
CSB-PA006124 | SERPINA1 Antibody |
Human | WB, ELISA |
CSB-PA213215 | SERPINA1 Antibody |
Human | ELISA,IHC |
CSB-PA213997 | SERPINA1 Antibody |
Human | ELISA,IHC |
CSB-PA799490 | SERPINA1 Antibody |
Human | ELISA,WB,IHC |
CSB-PA12565A0Rb | SERPINA1 Antibody |
Human | ELISA |
CSB-PA12565B0Rb | SERPINA1 Antibody, HRP conjugated |
Human | ELISA |
CSB-PA12565C0Rb | SERPINA1 Antibody, FITC conjugated |
Human | |
CSB-PA12565D0Rb | SERPINA1 Antibody, Biotin conjugated |
Human | ELISA |
SERPINA1 Antibodies for Rattus norvegicus (Rat)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA021053HD01RA | Serpina1 Antibody, Biotin conjugated |
Rat | ELISA |
CSB-PA021053HA01RA | Serpina1 Antibody |
Rat | ELISA |
SERPINA1 Proteins for Rattus norvegicus (Rat)
Code | Product Name | Source |
---|---|---|
CSB-YP021053RA | Recombinant Rat Alpha-1-antiproteinase (Serpina1) |
Yeast |
CSB-EP021053RA | Recombinant Rat Alpha-1-antiproteinase (Serpina1) |
E.coli |
CSB-BP021053RA CSB-MP021053RA CSB-EP021053RA-B |
Recombinant Rat Alpha-1-antiproteinase (Serpina1) |
Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SERPINA1 Proteins for Bos taurus (Bovine)
Code | Product Name | Source |
---|---|---|
CSB-YP021053BO CSB-EP021053BO CSB-BP021053BO CSB-MP021053BO CSB-EP021053BO-B |
Recombinant Bovine Alpha-1-antiproteinase (SERPINA1) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SERPINA1 Proteins for Sus scrofa (Pig)
Code | Product Name | Source |
---|---|---|
CSB-YP021053PI CSB-EP021053PI CSB-BP021053PI CSB-MP021053PI CSB-EP021053PI-B |
Recombinant Pig Alpha-1-antitrypsin (SERPINA1) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SERPINA1 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP021053HU CSB-EP021053HU CSB-BP021053HU CSB-MP021053HU CSB-EP021053HU-B |
Recombinant Human Alpha-1-antitrypsin (SERPINA1) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SERPINA1 Proteins for Papio anubis (Olive baboon)
Code | Product Name | Source |
---|---|---|
CSB-YP021053ERI CSB-EP021053ERI CSB-BP021053ERI CSB-MP021053ERI CSB-EP021053ERI-B |
Recombinant Papio anubis Alpha-1-antitrypsin (SERPINA1) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SERPINA1 Proteins for Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)
Code | Product Name | Source |
---|---|---|
CSB-YP021053DSU CSB-EP021053DSU CSB-BP021053DSU CSB-MP021053DSU CSB-EP021053DSU-B |
Recombinant Chlorocebus aethiops Alpha-1-antitrypsin (SERPINA1) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SERPINA1 Proteins for Mus caroli (Ryukyu mouse) (Ricefield mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP328635MUU CSB-EP328635MUU CSB-BP328635MUU CSB-MP328635MUU CSB-EP328635MUU-B |
Recombinant Mus caroli Alpha-1-antiproteinase (Serpina1) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SERPINA1 Proteins for Mus saxicola (Brown spiny mouse) (Rock-loving mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP720553MKR CSB-EP720553MKR CSB-BP720553MKR CSB-MP720553MKR CSB-EP720553MKR-B |
Recombinant Mus saxicola Alpha-1-antiproteinase (Serpina1) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SERPINA1 Proteins for Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Code | Product Name | Source |
---|---|---|
CSB-YP732764PYX CSB-EP732764PYX CSB-BP732764PYX CSB-MP732764PYX CSB-EP732764PYX-B |
Recombinant Pongo abelii Alpha-1-antitrypsin (SERPINA1) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SERPINA1 ELISA Kit for Homo sapiens (Human)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E11719h | Human α1-Antitrypsin,α1-AT ELISA Kit |
serum, plasma | 19.5 nIU/mL |
SERPINA1 ELISA Kit for Rattus norvegicus (Rat)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-EL021053RA | Rat Alpha-1-antitrypsin(SERPINA1) ELISA kit |
serum, plasma, tissue homogenates | 15.6 ng/mL |