SLC7A11 as a protein with altered expression upon KRAS mutation, resulting in rewiring of glutathione metabolism. SLC7A11 is the functional light chain subunit of the cystine/glutamate antiporter system. SLC7A11 is overexpressed in several cancer types, including glioma, liver carcinoma, non–small cell lung cancer, and triple-negative breast cancer, and serves as an independent prognostic factor. SLC7A11 also contributes to glutathione-based drug resistance.
Recombinant Human Cystine/glutamate transporter(SLC7A11)(Code:CSB-CF892171HU(A4))
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human SLC7A11 at 2 μg/ml can bind Anti-SLC7A11 recombinant antibody (CSB-RA892171MA1HU), the EC50 is 4.482-14.21 ng/mL.
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human SLC7A11 at 2 μg/ml can bind Anti-SLC7A11 recombinant antibody (CSB-RA892171MA2HU), the EC50 is 117.4-345.4 ng/mL.
The following SLC7A11 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
SLC7A11 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA145393 | SLC7A11 Antibody |
Human,Mouse | ELISA,WB,IHC |
SLC7A11 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP894813MO CSB-EP894813MO CSB-BP894813MO CSB-MP894813MO CSB-EP894813MO-B |
Recombinant Mouse Cystine/glutamate transporter (Slc7a11), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SLC7A11 Proteins for Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Code | Product Name | Source |
---|---|---|
CSB-YP735762PYX CSB-EP735762PYX CSB-BP735762PYX CSB-MP735762PYX CSB-EP735762PYX-B |
Recombinant Pongo abelii Cystine/glutamate transporter (SLC7A11), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SLC7A11 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP892171HU CSB-EP892171HU CSB-BP892171HU CSB-MP892171HU CSB-EP892171HU-B |
Recombinant Human Cystine/glutamate transporter (SLC7A11), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-CF892171HU(A4) | Recombinant Human Cystine/glutamate transporter (SLC7A11) (Active) |
in vitro E.coli expression system |
CSB-MP892171HU(A4) | Recombinant Human Cystine/glutamate transporter (SLC7A11)-VLPs |
Mammalian cell |