SELL, or selectin L, is a cell surface glycoprotein that is a member of the selectin family. It is expressed predominantly on the surface of leukocytes, particularly lymphocytes, and is also expressed on vascular endothelial cells.The mechanism of action of SELL involves cell adhesion and migration, which facilitates the movement of leukocytes from the bloodstream into tissues where inflammation or immune response occurs by interacting with molecules, such as heparan sulphate on the surface of vascular endothelial cells.The signalling pathways in which SELL is involved include signalling upon binding to ligands, which may lead to changes in intracellular calcium levels and reorganisation of the cytoskeleton, thereby regulating cell motility. Biologically, SELL is essential for the homing of lymphocytes to lymphoid organs and for their involvement in immune surveillance and inflammatory responses.Abnormal expression or dysfunction of SELL has been associated with the development of certain immune-related diseases, such as autoimmune diseases and chronic inflammatory diseases.
Validated Data
Western Blot analysis of K562 cells using L-Selectin Polyclonal Antibody
The following Sell reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
Sell Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA004858 | SELL Antibody |
Human,Mouse,Rat | WB, ELISA |
CSB-PA005603 | SELL Antibody |
Human,Mouse,Rat | WB, ELISA |
Sell Proteins for Papio hamadryas (Hamadryas baboon)
Code | Product Name | Source |
---|---|---|
CSB-YP630697ERJ CSB-EP630697ERJ CSB-BP630697ERJ CSB-MP630697ERJ CSB-EP630697ERJ-B |
Recombinant Papio hamadryas L-selectin (SELL), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Sell Proteins for Pongo pygmaeus (Bornean orangutan)
Code | Product Name | Source |
---|---|---|
CSB-YP822052EXP CSB-EP822052EXP CSB-BP822052EXP CSB-MP822052EXP CSB-EP822052EXP-B |
Recombinant Pongo pygmaeus L-selectin (SELL), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Sell Proteins for Macaca mulatta (Rhesus macaque)
Code | Product Name | Source |
---|---|---|
CSB-YP839159MOW CSB-EP839159MOW CSB-BP839159MOW CSB-MP839159MOW CSB-EP839159MOW-B |
Recombinant Macaca mulatta L-selectin (SELL), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Sell Proteins for Pan troglodytes (Chimpanzee)
Code | Product Name | Source |
---|---|---|
CSB-YP846458EQV CSB-EP846458EQV CSB-BP846458EQV CSB-MP846458EQV CSB-EP846458EQV-B |
Recombinant Pan troglodytes L-selectin (SELL), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Sell Proteins for Bos taurus (Bovine)
Code | Product Name | Source |
---|---|---|
CSB-CF020977BO | Recombinant Bovine L-selectin (SELL) |
in vitro E.coli expression system |
CSB-YP020977BO1 CSB-EP020977BO1 CSB-BP020977BO1 CSB-MP020977BO1 CSB-EP020977BO1-B |
Recombinant Bovine L-selectin (SELL), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Sell Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-CF020977HU | Recombinant Human L-selectin (SELL) |
in vitro E.coli expression system |
CSB-YP020977HU1 CSB-EP020977HU1 CSB-BP020977HU1 CSB-MP020977HU1 CSB-EP020977HU1-B |
Recombinant Human L-selectin (SELL), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Sell Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-CF020977MO | Recombinant Mouse L-selectin (Sell) |
in vitro E.coli expression system |
CSB-YP020977MO1 CSB-EP020977MO1 CSB-BP020977MO1 CSB-MP020977MO1 CSB-EP020977MO1-B |
Recombinant Mouse L-selectin (Sell), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Sell Proteins for Rattus norvegicus (Rat)
Code | Product Name | Source |
---|---|---|
CSB-CF020977RA | Recombinant Rat L-selectin (Sell) |
in vitro E.coli expression system |
CSB-YP020977RA1 CSB-EP020977RA1 CSB-BP020977RA1 CSB-MP020977RA1 CSB-EP020977RA1-B |
Recombinant Rat L-selectin (Sell), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Sell ELISA Kit for Mus musculus (Mouse)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E04654m | Mouse L-Selectin ELISA kit |
serum, plasma, tissue homogenates | 0.005 ng/mL |
Sell ELISA Kit for Homo sapiens (Human)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E04653h | Human L-Selectin ELISA kit |
serum, plasma, tissue homogenates | 0.195 ng/mL |
Sell ELISA Kit for Rattus norvegicus (Rat)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E07431r | Rat L-Selectin ELISA kit |
serum, plasma, tissue homogenates | 64 pg/mL |