Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A), also known as CD120a or TNFR1, is a type I transmembrane glycoprotein with a molecular weight of 55 kDa. TNFR1 is a member of the tumor necrosis factor (TNF) receptor superfamily and contains three parts, including extracellular domain, transmembrane domain and intracellular domain. The extracellular domain contains 182 amino acids and consists of four cysteine-rich domains (CRD1-CRD2-CRD3-CRD4). Each domain contains 6 conserved cysteine residues, contains 3 N glycosylation sites, and its function is mainly to bind to the trimeric form of TNF; the transmembrane region is between the extracellular domain and intracellular domains, it is about 22 amino acids long; the intracellular domain is about 223 amino acids long. The N-terminal residue is leucine. The C-terminus contains a death domain (DD) composed of 80 conserved amino acid sequences, which is necessary for the transduction of cell death signals, and many functions of TNFR1 are related to this domain.
TNFR1 has binding activity to TNF-α and TNF-β, and there are many studies on the binding of TNFR1 to TNF-α. When TNF-α binds to TNFR1, on the one hand, it can mediate apoptosis signal, cause apoptosis, play an important role in anti-tumor and anti-viral infection, and also participate in the damage to own tissue cells in autoimmune diseases and sepsis . TNFR1 can also mediate cell activation and proliferation signals, induce the activity of nitric oxide synthase and IL8, activate nuclear transcription factor (NF-κB) and activator protein 1. TNFR1 also induces the expression of intercellular adhesion factor 1 and IL6. As a popular biological target, TNFR1 has a dual role. A large number of studies have confirmed that the expression of TNFR1 can promote or inhibit the apoptosis of tumor cells and participate in autoimmune diseases.
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Popular Product
Recombinant Human Tumor necrosis factor receptor superfamily member 1A(TNFRSF1A),partial (Active) (CSB-MP023977HU1)
Validated Data
Purity determined
by
SDS-PAGE
Greater than 94% as determined by SDS-PAGE.
The binding activity of TNFα-TNFR1 validated by functional ELISA
Immobilized TNF-α (CSB-YP023955HU) at 5 μg/ml can bind human TNFR1, the EC50 is 7.799-10.90 ng/ml.
The binding activity of LAT-TNFR1 validated by functional ELISA
Immobilized LTA (CSB-MP013218HU) at 5 μg/ml can bind human TNFR1, the EC50 is 4.409-6.797 ng/ml.
