TNIK, TRAF2 and NCK interacting kinase, is a protein belonging to the family of germinal centre kinases. It plays a role in a variety of biological processes, including cytoskeleton construction, neural dendritic cell extension, and embryonic development.The mechanism of action of TNIK involves interactions with a variety of signalling pathways, in particular the Wnt/β-catenin signalling pathway, in which TNIK, as a part of the β-catenin/TCF4 transcriptional complex, is transcriptional activation of Wnt target genes which TNIK, as part of the β-catenin/TCF4 transcriptional complex, is critical for the transcriptional activation of Wnt target genes. In addition, TNIK is involved in the regulation of the TGFβ/SMAD signalling pathway, which affects epithelial-mesenchymal transition (EMT) and metastasis of tumour cells. Biologically, TNIK plays a key role in tissue regeneration, immune response, and tumour development, and is a potential therapeutic target for many diseases, including fibrotic diseases and certain cancers.
TNIK Antibody (CSB-PA023998LA01HU)
Validated Data
Immunohistochemistry of paraffin-embedded human appendix tissue using CSB-PA023998LA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA023998LA01HU at dilution of 1:100
Immunofluorescent analysis of Hela cells using CSB-PA023998LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
The following Tnik reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
Tnik Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA023998LA01HU | TNIK Antibody |
Human | ELISA, IHC, IF |
CSB-PA023998LB01HU | TNIK Antibody, HRP conjugated |
Human | ELISA |
CSB-PA023998LC01HU | TNIK Antibody, FITC conjugated |
Human | |
CSB-PA023998LD01HU | TNIK Antibody, Biotin conjugated |
Human | ELISA |
Tnik Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP890916HU CSB-EP890916HU CSB-BP890916HU CSB-MP890916HU CSB-EP890916HU-B |
Recombinant Human TRAF2 and NCK-interacting protein kinase (TNIK), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |