TREM2, or myeloid triggered receptor 2, is a transmembrane receptor protein expressed mainly in microglia of the central nervous system.TREM2 recognises a variety of ligands through its extracellular immunoglobulin structural domain, including pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs). Its mechanism of action involves the activation of downstream signalling pathways upon binding to ligands, mainly through binding to DAP12, which activates Syk kinase, which in turn triggers a variety of signalling pathways including PI3K, PLCγ and RAS/MEK/ERK. These signalling pathways affect microglia phagocytosis, cell survival, metabolic homeostasis and inflammatory responses. Biologically, TREM2 plays an important role in maintaining the homeostasis of the central nervous system, regulating the immune response and participating in the pathogenesis of neurodegenerative diseases.Abnormal activation of TREM2 signalling is closely related to the development of neurodegenerative diseases such as Alzheimer's disease, and it is one of the hotspots of current neuroscience research.
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
TREM2 Antibody (CSB-PA024405LA01HU)
Validated Data
Immunohistochemistry of paraffin-embedded human melanoma using CSB-PA024405LA01HU at dilution of 1:100
Immunofluorescence staining of HepG2 cells with CSB-PA024405LA01HU at 1:166, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Human Triggering receptor expressed on myeloid cells 2(TREM2) ELISA kit (CSB-EL024405HU)
Validated Data
Code: CSB-EL024405HU
Size: 96T,5×96T,10×96T
Sensitivity: 0.078 ng/mL
Detection Range: 0.312 ng/mL-20 ng/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
The following Trem2 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
Trem2 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA436852 | TREM2 Antibody |
Human,Mouse | ELISA,WB |
CSB-PA024405LA01HU | TREM2 Antibody |
Human | ELISA, IHC, IF |
CSB-PA024405LB01HU | TREM2 Antibody, HRP conjugated |
Human | ELISA |
CSB-PA024405LC01HU | TREM2 Antibody, FITC conjugated |
Human | |
CSB-PA024405LD01HU | TREM2 Antibody, Biotin conjugated |
Human | ELISA |
Trem2 Antibodies for Mus musculus (Mouse)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA024405LA01MO | Trem2 Antibody |
Mouse, Human | ELISA, WB |
CSB-PA024405LD01MO | Trem2 Antibody, Biotin conjugated |
Mouse | ELISA |
CSB-PA024405LC01MO | Trem2 Antibody, FITC conjugated |
Mouse | |
CSB-PA024405LB01MO | Trem2 Antibody, HRP conjugated |
Mouse | ELISA |
Trem2 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP024405MO CSB-BP024405MO CSB-EP024405MO-B |
Recombinant Mouse Triggering receptor expressed on myeloid cells 2 (Trem2), partial |
Yeast Baculovirus In Vivo Biotinylation in E.coli |
CSB-EP024405MO | Recombinant Mouse Triggering receptor expressed on myeloid cells 2 (Trem2), partial |
E.coli |
CSB-MP024405MO | Recombinant Mouse Triggering receptor expressed on myeloid cells 2 (Trem2), partial |
Mammalian cell |
Trem2 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP024405HU | Recombinant Human Triggering receptor expressed on myeloid cells 2 (TREM2), partial |
Yeast |
CSB-EP024405HU | Recombinant Human Triggering receptor expressed on myeloid cells 2 (TREM2), partial |
E.coli |
CSB-BP024405HU CSB-EP024405HU-B |
Recombinant Human Triggering receptor expressed on myeloid cells 2 (TREM2), partial |
Baculovirus In Vivo Biotinylation in E.coli |
CSB-MP024405HU | Recombinant Human Triggering receptor expressed on myeloid cells 2 (TREM2), partial |
Mammalian cell |
CSB-EP024405HUd1 | Recombinant Human Triggering receptor expressed on myeloid cells 2 (TREM2), partial |
E.coli |
Trem2 ELISA Kit for Homo sapiens (Human)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-EL024405HU | Human Triggering receptor expressed on myeloid cells 2(TREM2) ELISA kit |
serum, plasma, tissue homogenates | 0.078 ng/mL |
Trem2 ELISA Kit for Mus musculus (Mouse)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-EL024405MO | Mouse Triggering receptor expressed on myeloid cells 2(TREM2) ELISA kit |
serum, plasma, tissue homogenates | 0.039 ng/mL |