TYMS (thymidylate synthase) is a crucial enzyme in the DNA synthesis process, a dimeric protein composed of two identical subunits located on chromosome 18. Its primary function is to catalyze the conversion of deoxyuridine monophosphate (dUMP) and 5,10-methylenetetrahydrofolate (FH4) into deoxythymidine monophosphate (dTMP), a reaction that is vital for cellular DNA replication and repair. TYMS plays a central role in cell growth and proliferation, and its expression level is often elevated in tumor cells, closely associated with tumor cell proliferation, invasion, and metastasis. Consequently, TYMS has become an important target for anticancer drugs. Chemotherapeutic agents such as 5-fluorouracil (5-FU) inhibit TYMS activity, preventing DNA synthesis and thereby suppressing tumor cell growth. Research on TYMS not only aids in understanding cellular biological processes but also provides new avenues for the development of anticancer drugs.
The following Tyms reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
Tyms Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA025393GA01HU | TYMS Antibody |
Human,Mouse,Rat | ELISA,WB,IHC,IF |
CSB-PA025393LA01HU | TYMS Antibody |
Human | ELISA, WB, IF, IP |
CSB-PA025393LB01HU | TYMS Antibody, HRP conjugated |
Human | ELISA |
CSB-PA025393LC01HU | TYMS Antibody, FITC conjugated |
Human | |
CSB-PA025393LD01HU | TYMS Antibody, Biotin conjugated |
Human | ELISA |
CSB-RA584889A0HU | TYMS Recombinant Monoclonal Antibody |
Human | ELISA, WB |
Tyms Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP025393HU CSB-EP025393HU CSB-BP025393HU CSB-MP025393HU CSB-EP025393HU-B |
Recombinant Human Thymidylate synthase (TYMS) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Tyms ELISA Kit for Homo sapiens (Human)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E10815h | Human thymidylate synthetase,TS ELISA Kit |
serum, plasma, cell culture supernates, tissue homogenates | 0.078 ng/mL |