Mannose receptor 1 (MCR1), also known as CD206, is a transmembrane protein with a relative molecular mass of 166 kDa. It is a marker of M2 macrophages with high specificity. MCR1 is mainly distributed on the surface of most macrophages and immature dendritic cells, and acts as a pattern recognition receptor to recognize glycoproteins and glycolipids on the surface of pathogens, so it plays a role in antigen recognition and antigen presentation. In addition, MCR1 also plays a role in the clearance of sulfated glycoprotein hormones and glycoproteins produced under pathological conditions in the systemic circulation. A soluble form of MCR1 is found in the periphery after proteolytic cleavage of the macrophage membrane. The soluble form of MCR1, similar to the membrane form, also recognizes sulfated and mannosylated carbohydrates and can alter innate and adaptive immune responses.
Research shows that tumor-associated macrophages participate in the tumor microenvironment and can promote the formation and metastasis of various tumors. M2-type tumor-associated macrophages are the majority, which are found in breast cancer, ovarian cancer, pancreatic cancer and prostate cancer. Traces of it can be found. As a marker of M2 macrophages, MCR1 is highly specific and can be used as a potential marker for the diagnosis of malignant tumors.
The following mrc1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
mrc1 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA014782GA01HU | MRC1 Antibody |
Human | ELISA,WB,IHC |
CSB-PA106212 | MRC1 Antibody |
Human | ELISA,WB |
CSB-PA010220 | MRC1 Antibody |
Human,Mouse,Rat | WB, ELISA |
CSB-PA941963 | MRC1 Antibody |
Human | ELISA,IHC |
CSB-PA006303 | MRC1 Antibody |
Human | WB, ELISA |
CSB-PA014783LA01HU | MRC1 Antibody |
Human | ELISA |
CSB-PA014783LD01HU | MRC1 Antibody, Biotin conjugated |
Human | ELISA |
CSB-PA014783LC01HU | MRC1 Antibody, FITC conjugated |
Human | |
CSB-PA014783LB01HU | MRC1 Antibody, HRP conjugated |
Human | ELISA |
mrc1 Antibodies for Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA338680XA01SVG | MRC1 Antibody |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | ELISA, WB |
mrc1 Antibodies for Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA889248XA01SXV | mrc1 Antibody |
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) | ELISA, WB (ensure identification of antigen) |
mrc1 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP014783HU | Recombinant Human Macrophage mannose receptor 1 (MRC1), partial |
Yeast |
CSB-EP014783HU | Recombinant Human Macrophage mannose receptor 1 (MRC1), partial |
E.coli |
CSB-BP014783HU CSB-MP014783HU CSB-EP014783HU-B |
Recombinant Human Macrophage mannose receptor 1 (MRC1), partial |
Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-EP014783HUa0 | Recombinant Human Macrophage mannose receptor 1 (MRC1), partial |
E.coli |
mrc1 Proteins for Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Code | Product Name | Source |
---|---|---|
CSB-YP338680SVG CSB-EP338680SVG CSB-BP338680SVG CSB-MP338680SVG CSB-EP338680SVG-B |
Recombinant Saccharomyces cerevisiae Mediator of replication checkpoint protein 1 (MRC1), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
mrc1 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP723429MO CSB-EP723429MO CSB-BP723429MO CSB-MP723429MO CSB-EP723429MO-B |
Recombinant Mouse Macrophage mannose receptor 1 (Mrc1), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
mrc1 Proteins for Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Code | Product Name | Source |
---|---|---|
CSB-YP889248SXV CSB-EP889248SXV CSB-BP889248SXV CSB-MP889248SXV CSB-EP889248SXV-B |
Recombinant Schizosaccharomyces pombe Mediator of replication checkpoint protein 1 (mrc1), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
mrc1 ELISA Kit for Mus musculus (Mouse)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-EL014782MO | Mouse Macrophage mannose receptor 1(MRC1) ELISA kit |
serum, plasma, tissue homogenates, cell lysates | 0.156 ng/mL |
mrc1 ELISA Kit for Homo sapiens (Human)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E09961h | Human mannose receptor,MR ELISA Kit |
serum, plasma, tissue homogenates, cell lysates | 0.039 ng/mL |