TP53 (also known as p53) is a transcription factor comprising multiple functional domains, such as the DNA-binding domain, transcription activation domain, and nuclear localization signal. It plays a crucial role in monitoring DNA damage and maintaining genomic stability within cells. When cells undergo damage or stress, p53 is activated, promoting the repair of damaged DNA or inducing apoptosis in the affected cells. This aids in preventing the spread of DNA damage, inhibiting abnormal proliferation of damaged cells, and thwarting tumor formation. The signaling pathway activated by p53 involves interactions among various molecules and proteins, including sensing DNA damage signals, initiating DNA repair, and cell apoptosis pathways. As a tumor suppressor gene, p53 plays a critical role within cells, being vital for maintaining genomic stability and preventing the occurrence of tumors.
Popular Product:
Recombinant Human Cellular tumor antigen p53 (TP53)
Validated Data
SDS-PAGE
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
LC-MS/MS
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP024077HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) TP53.
LC-MS/MS
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP024077HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) TP53.
The following tp53 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
tp53 Proteins
tp53 Proteins for Equus caballus (Horse)
tp53 Proteins for Bos taurus (Bovine)
tp53 Proteins for Gallus gallus (Chicken)
tp53 Proteins for Felis catus (Cat) (Felis silvestris catus)
tp53 Proteins for Ovis aries (Sheep)
tp53 Proteins for Macaca mulatta (Rhesus macaque)
tp53 Proteins for Homo sapiens (Human)
tp53 Proteins for Mus musculus (Mouse)
tp53 Proteins for Bos indicus (Zebu)
tp53 Proteins for Oryzias latipes (Japanese rice fish) (Japanese killifish)
tp53 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)
tp53 Proteins for Rattus norvegicus (Rat)
tp53 Proteins for Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)
tp53 Proteins for Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
tp53 Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
tp53 Proteins for Macaca fuscata fuscata (Japanese macaque)
tp53 Proteins for Xenopus laevis (African clawed frog)
tp53 Proteins for Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
tp53 Proteins for Platichthys flesus (European flounder) (Pleuronectes flesus)
tp53 Proteins for Marmota monax (Woodchuck)
tp53 Proteins for Xiphophorus helleri (Green swordtail)
tp53 Proteins for Ictalurus punctatus (Channel catfish) (Silurus punctatus)
tp53 Proteins for Canis lupus familiaris (Dog) (Canis familiaris)
tp53 Proteins for Equus asinus (Donkey) (Equus africanus asinus)
tp53 Proteins for Spermophilus beecheyi (California ground squirrel) (Otospermophilus beecheyi)
tp53 Proteins for Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus)
tp53 Proteins for Delphinapterus leucas (Beluga whale)
tp53 Proteins for Oryctolagus cuniculus (Rabbit)
tp53 Proteins for Tupaia belangeri (Common tree shrew) (Tupaia glis belangeri)
tp53 Proteins for Sus scrofa (Pig)
tp53 Proteins for Cavia porcellus (Guinea pig)
tp53 Proteins for Barbus barbus (Barbel) (Cyprinus barbus)
tp53 Proteins for Tetraodon miurus (Congo puffer)
